This causes genome instability in the form of an increase of anaphase bridges at mitosis, which is indicated by the red arrows at the left and quantitated in the graph at the right. A number of human genetic diseases are linked to mutations in genes that regulate the epigenome for example, Rett syndrome is caused by mutations in a gene that binds to methylated DNA.
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person.
Oral-facial-digital syndrome is actually a group of related conditions that affect the development of the oral cavity the mouth and teeth , facial features, and digits fingers and toes. Researchers have identified at least 13 potential forms of oral-facial-digital syndrome.
C , C HPO: Immunodeficiency, centromeric instability, and facial dysmorphism ICF syndrome is a rare autosomal recessive disease characterized by facial dysmorphism, immunoglobulin deficiency, and branching of chromosomes 1, 9, and 16 after phytohemagglutinin PHA stimulation of lymphocytes.
Patients have been described as having variable oculofacial features including epicanthal folds, hypertelorism, strabismus, and 'tapetoretinal degeneration'. The full phenotype is variable and unknown based on the 5 reported patients from 4 families of whom 3 were consanguineous.
ICF syndrome is a recessive disease characterized by decreased levels of serum immunoglobulins in the presence of B cells, as well as chromatin decondensation and rearrangements, and satellite DNA hypomethylation specifically in the juxtacentromeric heterochromatin of chromosomes 1, 9, and Handbook of Epigenetics,
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ICF syndrome or I mmunodeficiency, C entromere instability and F acial anomalies syndrome  is a merest rare autosomal recessive  vaccinated disarrange. It is characterized about uncertain reductions in serum immunoglobulin levels which compel greater ICF patients to submit to transmissible diseases to come adulthood.
Genetic diseases, Immune diseases. Immunodeficiency Syndrome, Variable 53
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